CRYBB3

Across TCGA pan-cancer cohorts, CRYBB3 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CRYBB3 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CRYBB3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CRYBB3 expression acts as an unfavorable survival marker, although some lineages such as BLCA and HNSC show a favorable association.

ACC, COAD, and BLCA are the cancer types where CRYBB3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.416	0.897	<.001	132	view →
COAD	OS	Quartile	All	0.658	0.901	.001	98	view →
BLCA	DFS	Quartile	IV	0.699	0.375	<.001	33	view →
HNSC	OS	Median	All	0.813	0.689	<.001	30	view →
LUSC	OS	Median	All	0.722	0.596	.003	23	view →
UVM	DFS	Tertile	III,IV	0.353	0.725	.009	19	view →
PRAD	DFS	Median	All	0.675	0.888	<.001	18	view →
LUAD	OS	Median	II,III,IV	0.441	0.185	.011	17	view →
SCLC	DFS	Quartile	All	1.000	0.366	.016	13	view →
PAAD	OS	Quartile	All	0.449	0.713	.010	12	view →
MESO	OS	Median	All	0.271	0.694	.002	12	view →
PCPG	OS	Median	All	1.000	0.729	.015	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CRYBB3–ACC (DFS)

Open the ACC breakdown →