CRYBA2

Across TCGA cell cohorts, CRYBA2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CRYBA2-associated genes across cancer lineages are OR6Q1, IL36B, and CLRN1. Each is linked with CRYBA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYBA2-to-partner and partner-to-CRYBA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6Q1 grouped by CRYBA2-low versus CRYBA2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBA2→partner) and Y-score (partner→CRYBA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR6Q1 →	+0.030	+6.022	<.001	.001	3	1
BLOOD_Lymphoma	IL36B →	+0.021	+5.209	.001	.005	3	1
BLOOD_Lymphoma	CLRN1 →	+0.012	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	POTED →	+1.083	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR10H5 →	+0.119	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	MRGPRE →	+0.019	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

OR6Q1 by CRYBA2 expression — LARGE_INTESTINE

Explore this box plot interactively →