CRTAP

Across TCGA patient cohorts, CRTAP mutation is significantly associated with the RNA expression of many other genes, with 955 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRTAP-associated genes across cancer lineages are MIR8052, OR4C46, and RNU6-1313P. Each is linked with CRTAP in more than 1 cancer types. Because this analysis shows association rather than direction, both CRTAP-to-partner and partner-to-CRTAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8052 grouped by CRTAP-low versus CRTAP-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRTAP→partner) and Y-score (partner→CRTAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR8052 →	+0.501	+7.731	<.001	.009	3	1
COAD	OR4C46 →	+0.179	+7.741	<.001	.009	3	1
COAD	RNU6-1313P →	+0.593	+7.741	<.001	.009	3	1
COAD	RNU6-533P →	+0.571	+7.741	<.001	.009	3	1
BLCA	RNU6-74P →	+0.349	+5.106	<.001	.008	3	1
BLCA	MIR301A →	+0.611	+5.251	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 955 associations by consensus.

MIR8052 by CRTAP expression — BRCA

Explore this box plot interactively →