CRTAP

Across TCGA pan-cancer cohorts, CRTAP RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CRTAP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CRTAP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CRTAP is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.

KIRC, LIHC, and KIRP are the cancer types where CRTAP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRTAP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.682	<.001	11	view →
LIHC	Female	II,III,IV	+1.465	<.001	9	view →
KIRP	Female	II,III,IV	+1.340	<.001	9	view →
BLCA	Male	IV	−2.055	<.001	8	view →
UCEC	All	All	−1.443	<.001	8	view →
LUAD	Female	III,IV	−0.716	<.001	8	view →
LUSC	Male	All	−0.632	<.001	8	view →
HNSC	All	All	+0.410	.001	7	view →
BRCA	All	All	−0.881	<.001	6	view →
CHOL	All	All	+1.375	<.001	5	view →
COAD	All	All	+0.270	.037	4	view →
PRAD	All	All	−0.469	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CRTAP–KIRC

Open the KIRC breakdown →