CROCC

Across TCGA patient cohorts, CROCC protein abundance is significantly associated with the RNA expression of many other genes, with 18,558 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CROCC-associated genes across cancer lineages are DRC3, KLF3-AS1, and C2orf73. Each is linked with CROCC in more than 6 cancer types. Because this analysis shows association rather than direction, both CROCC-to-partner and partner-to-CROCC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CROCC versus DRC3 in BRCA, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CROCC→partner) and Y-score (partner→CROCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DRC3 →	+1.021	+0.404	<.001	<.001	3	7
UCEC	KLF3-AS1 →	+0.798	+0.517	.002	.005	3	7
UCEC	C2orf73 →	+1.116	+0.634	<.001	<.001	3	7
UCEC	GARS1 →	-0.541	-0.577	<.001	<.001	3	6
BRCA	E2F1 →	-1.097	-0.366	<.001	<.001	3	6
LUAD	CENPI →	-0.974	-0.293	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,558 associations by consensus.

CROCC vs DRC3 — BRCA

Explore this scatter interactively →