CROCC

Across TCGA pan-cancer cohorts, CROCC RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CROCC’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CROCC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CROCC is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

COAD, LIHC, and HNSC are the cancer types where CROCC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CROCC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+0.776	<.001	11	view →
LIHC	Female	II,III,IV	+1.199	<.001	8	view →
HNSC	Male	III,IV	+1.081	<.001	8	view →
KICH	Male	All	−0.860	<.001	8	view →
UCEC	All	All	−1.073	<.001	6	view →
CHOL	Female	All	+2.046	<.001	5	view →
KIRC	Female	All	+0.371	.005	4	view →
BRCA	Female	II,III,IV	−0.297	.013	4	view →
STAD	Male	II,III,IV	+0.854	.010	3	view →
BLCA	Female	III,IV	+0.584	.025	1	view →
READ	All	All	+0.568	.031	1	view →
LUAD	All	All	−0.361	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CROCC–COAD

Open the COAD breakdown →