CRNN

Across TCGA cell cohorts, CRNN mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CRNN-associated genes across cancer lineages are SMIM33, DPPA4, and FAM216B. Each is linked with CRNN in more than 1 cancer types. Because this analysis shows association rather than direction, both CRNN-to-partner and partner-to-CRNN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM33 grouped by CRNN-low versus CRNN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRNN→partner) and Y-score (partner→CRNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SMIM33 →	+0.500	+2.648	.001	.008	3	2
SOFT_TISSUE	DPPA4 →	+1.432	+3.678	<.001	.009	3	1
SOFT_TISSUE	FAM216B →	+0.153	+3.736	.005	.008	3	1
SOFT_TISSUE	OR1J2 →	+0.034	+3.635	<.001	.007	3	1
SOFT_TISSUE	H2AB1 →	+0.166	+3.736	.008	.008	3	1
SOFT_TISSUE	H4C6 →	+0.092	+4.392	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SMIM33 by CRNN expression — LARGE_INTESTINE

Explore this box plot interactively →