CRNN

Across TCGA pan-cancer cohorts, CRNN RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of CRNN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CRNN RNA is repressed in tumor relative to normal tissue. In most cancer types CRNN is over-expressed in tumor, although a few such as HNSC and PRAD show the opposite, repressed pattern.

HNSC, KIRC, and UCEC are the cancer types where CRNN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRNN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−7.880	<.001	12	view →
KIRC	All	III,IV	+0.031	.012	6	view →
UCEC	All	All	+0.214	.021	4	view →
LUSC	Male	All	+0.897	.001	3	view →
PRAD	All	All	−0.188	.040	2	view →
KIRP	Male	All	−0.128	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

CRNN–HNSC

Open the HNSC breakdown →