CRKL

Across TCGA patient cohorts, CRKL mutation is significantly associated with the RNA expression of many other genes, with 3,551 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRKL-associated genes across cancer lineages are RNU6-73P, TRAJ45, and FAM207CP. Each is linked with CRKL in more than 1 cancer types. Because this analysis shows association rather than direction, both CRKL-to-partner and partner-to-CRKL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-73P grouped by CRKL-low versus CRKL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRKL→partner) and Y-score (partner→CRKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-73P →	+0.118	+2.766	.007	.003	3	2
COAD	TRAJ45 →	+0.942	+4.085	.002	.005	3	2
SKCM	FAM207CP →	+0.064	+4.385	<.001	.008	3	2
UCEC	KMT5AP1 →	+0.253	+2.556	<.001	<.001	3	1
UCEC	CCDC163 →	+0.533	+2.502	<.001	<.001	3	1
UCEC	EBLN3P →	+0.451	+3.475	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,551 associations by consensus.

RNU6-73P by CRKL expression — UCEC

Explore this box plot interactively →