CRKL

Across TCGA pan-cancer cohorts, CRKL RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CRKL’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CRKL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CRKL is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where CRKL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRKL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.330	<.001	12	view →
KIRC	Female	III,IV	+0.621	<.001	12	view →
LIHC	Male	All	+0.827	<.001	9	view →
LUSC	Male	II,III,IV	+1.189	<.001	7	view →
THCA	All	All	−0.330	<.001	7	view →
BLCA	All	All	+0.658	.017	6	view →
CHOL	Male	All	+1.763	<.001	4	view →
STAD	All	II,III,IV	+0.590	.012	4	view →
COAD	Male	All	+0.305	.002	4	view →
KICH	All	All	−0.575	.001	2	view →
PAAD	Male	All	+0.450	.025	2	view →
READ	All	III,IV	+0.434	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CRKL–HNSC

Open the HNSC breakdown →