CRB2

Across TCGA cell cohorts, CRB2 mutation is significantly associated with the mutation status of many other genes, with 5,672 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRB2-associated genes across cancer lineages are GPR158, ANKRD11, and CORO7. Each is linked with CRB2 in more than 4 cancer types. Because this analysis shows association rather than direction, both CRB2-to-partner and partner-to-CRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR158 grouped by CRB2-low versus CRB2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRB2→partner) and Y-score (partner→CRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GPR158 →	+3.217	+3.684	.006	.006	1	5
BLOOD_Leukemia	ANKRD11 →	+2.315	+3.567	<.001	<.001	1	5
BLOOD_Lymphoma	CORO7 →	+6.169	+6.169	<.001	<.001	1	5
OVARY	RREB1 →	+2.824	+4.347	.001	.001	1	5
BLOOD_Leukemia	ZZEF1 →	+2.817	+2.669	.001	.001	1	5
BLOOD_Leukemia	ADAMTS19 →	+3.080	+2.675	.004	.004	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,672 associations by consensus.

GPR158 by CRB2 expression — OVARY

Explore this box plot interactively →