CRB2

Across TCGA pan-cancer cohorts, CRB2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CRB2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CRB2 RNA is repressed in tumor relative to normal tissue. In most cancer types CRB2 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and KICH are the cancer types where CRB2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRB2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	−3.122	<.001	9	view →
KIRC	Male	All	−1.695	<.001	9	view →
KICH	Female	All	−2.324	<.001	7	view →
UCEC	All	All	−2.112	<.001	6	view →
BRCA	Female	All	−0.885	<.001	6	view →
LUAD	Female	III,IV	−0.174	.004	3	view →
READ	Male	All	−1.383	.018	2	view →
COAD	All	IV	+0.659	.033	2	view →
BLCA	All	All	−0.294	.035	2	view →
LIHC	Female	III,IV	+0.054	.029	2	view →
HNSC	Female	IV	−0.211	.026	1	view →
THCA	All	All	−0.173	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CRB2–KIRP

Open the KIRP breakdown →