CPS1-IT1

Across TCGA patient cohorts, CPS1-IT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,834 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CPS1-IT1-associated GO terms across cancer lineages are Sulfur amino acid metabolic process, Response to purine-containing compound, and Pyrimidine nucleobase biosynthetic process. Each is linked with CPS1-IT1 in more than 6 cancer types. Because this analysis shows association rather than direction, both CPS1-IT1-to-partner and partner-to-CPS1-IT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sulfur amino acid metabolic process grouped by CPS1-IT1-low versus CPS1-IT1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CPS1-IT1→partner) and Y-score (partner→CPS1-IT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Sulfur amino acid metabolic process →	+0.042	+0.080	<.001	<.001	3	7
ESCA	Response to purine-containing compound →	+0.043	+0.081	<.001	<.001	3	6
ESCA	Pyrimidine nucleobase biosynthetic process →	+0.057	+0.106	<.001	<.001	2	7
ESCA	Alpha-amino acid metabolic process →	+0.039	+0.064	<.001	.006	2	7
ESCA	Neutral lipid metabolic process →	+0.044	+0.118	<.001	<.001	3	6
SKCM	Centriole assembly →	+0.030	+0.007	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,834 associations by consensus.

Sulfur amino acid metabolic process by CPS1-IT1 expression — ESCA

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