CPS1-IT1

Across TCGA pan-cancer cohorts, CPS1-IT1 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated CPS1-IT1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CPS1-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CPS1-IT1 expression acts as an unfavorable survival marker, although some lineages such as LIHC and BLCA show a favorable association.

LUAD, KIRP, and READ are the cancer types where CPS1-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.677	0.817	<.001	79	view →
KIRP	DFS	Tertile	All	0.158	0.616	<.001	66	view →
READ	DFS	Tertile	All	0.255	0.844	.004	54	view →
CHOL	OS	Tertile	III,IV	0.136	0.859	.003	36	view →
ESCA	OS	Tertile	All	0.205	0.911	<.001	36	view →
LIHC	OS	Quartile	All	0.678	0.366	<.001	21	view →
UCEC	DFS	Tertile	IV	0.206	0.704	.033	18	view →
BLCA	OS	Tertile	II,III,IV	1.000	0.415	.046	12	view →
SARC	DFS	Tertile	All	0.142	0.599	.001	12	view →
LUSC	DFS	Tertile	All	0.365	0.718	.014	9	view →
PRAD	DFS	Tertile	All	0.870	0.937	.040	6	view →
SKCM	OS	Tertile	All	0.149	0.403	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

CPS1-IT1–LUAD (DFS)

Open the LUAD breakdown →