CPS1-IT1

Across TCGA pan-cancer cohorts, CPS1-IT1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CPS1-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where CPS1-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types CPS1-IT1 is over-expressed in tumor, although a few such as LIHC and CHOL show the opposite, repressed pattern.

LIHC, LUAD, and CHOL are the cancer types where CPS1-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CPS1-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	II,III,IV	−0.208	.010	4	view →
LUAD	All	All	+0.072	.012	4	view →
CHOL	All	All	−0.945	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

CPS1-IT1–LIHC

Open the LIHC breakdown →