CPOX

Across TCGA patient cohorts, CPOX mutation is significantly associated with the RNA expression of many other genes, with 3,173 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPOX-associated genes across cancer lineages are MIR4422HG, PTCSC2, and LINC01399. Each is linked with CPOX in more than 1 cancer types. Because this analysis shows association rather than direction, both CPOX-to-partner and partner-to-CPOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4422HG grouped by CPOX-low versus CPOX-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPOX→partner) and Y-score (partner→CPOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR4422HG →	+0.155	+5.038	<.001	.009	3	2
READ	PTCSC2 →	+0.348	+6.681	<.001	<.001	3	2
UCEC	LINC01399 →	+0.152	+1.793	.002	.004	3	2
UCEC	RNA5SP410 →	+0.751	+2.526	<.001	<.001	3	2
UCEC	RNA5SP164 →	+0.082	+3.738	<.001	.009	3	2
COAD	RNU6-1180P →	+0.360	+5.824	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,173 associations by consensus.

MIR4422HG by CPOX expression — BLCA

Explore this box plot interactively →