CPOX

Across TCGA pan-cancer cohorts, CPOX RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated CPOX data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CPOX RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CPOX expression acts as an unfavorable survival marker, although some lineages such as READ and LUSC show a favorable association.

KIRP, LGG, and THCA are the cancer types where CPOX RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.765	0.917	.002	48	view →
LGG	DFS	Median	All	0.655	0.811	<.001	48	view →
THCA	OS	Median	All	0.956	0.991	.008	39	view →
ACC	DFS	Median	All	0.411	0.735	<.001	36	view →
KICH	DFS	Tertile	All	0.730	1.000	.010	35	view →
READ	OS	Median	II,III,IV	0.970	0.858	.006	29	view →
LUSC	OS	Quartile	All	0.857	0.716	.002	26	view →
MESO	OS	Quartile	All	0.400	0.680	.008	25	view →
LIHC	OS	Tertile	All	0.707	0.850	.001	24	view →
KIRC	DFS	Quartile	All	0.513	0.672	.009	22	view →
UVM	DFS	Quartile	III,IV	0.174	0.900	.001	19	view →
HNSC	OS	Tertile	All	0.652	0.847	.006	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

CPOX–KIRP (DFS)

Open the KIRP breakdown →