CPNE8

Across TCGA cell cohorts, CPNE8 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible CPNE8-associated genes across cancer lineages are SUPT20HL1, OR2C1, and DAZ3. Each is linked with CPNE8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPNE8-to-partner and partner-to-CPNE8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUPT20HL1 grouped by CPNE8-low versus CPNE8-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPNE8→partner) and Y-score (partner→CPNE8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SUPT20HL1 →	+0.007	+3.362	<.001	.007	3	2
LARGE_INTESTINE	OR2C1 →	+0.078	+3.648	.008	.002	3	2
BONE	DAZ3 →	+0.630	+5.169	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR2L5 →	+0.007	+3.887	.007	.002	3	1
LUNG_NSCLC_LUAD	KHDC3L →	+0.022	+3.215	.004	.007	3	1
OVARY	MYF5 →	+0.017	+4.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

SUPT20HL1 by CPNE8 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →