CPEB4

Across TCGA patient cohorts, CPEB4 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPEB4-associated genes across cancer lineages are p62 Lck ligand, Rad50, and TFRC. Each is linked with CPEB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPEB4-to-partner and partner-to-CPEB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CPEB4-low versus CPEB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPEB4→partner) and Y-score (partner→CPEB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.349	+1.906	<.001	<.001	3	2
UCEC	Rad50 →	-0.143	-1.115	.043	.026	3	2
UCEC	TFRC →	+0.319	+1.700	.038	.040	3	2
UCEC	ATM →	-0.471	-2.156	<.001	.002	3	2
UCEC	beta-Catenin →	+0.531	+1.906	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.585	+2.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

p62 Lck ligand by CPEB4 expression — UCEC

Explore this box plot interactively →