CPEB4

Across TCGA pan-cancer cohorts, CPEB4 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CPEB4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CPEB4 RNA is repressed in tumor relative to normal tissue. In most cancer types CPEB4 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and LUSC are the cancer types where CPEB4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CPEB4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.501	<.001	10	view →
KIRC	Male	II,III,IV	−0.806	<.001	9	view →
LUSC	Female	II,III,IV	−1.724	<.001	8	view →
HNSC	Male	III,IV	−0.998	<.001	8	view →
BLCA	All	All	−0.954	<.001	8	view →
COAD	Female	All	−0.815	<.001	7	view →
KIRP	Male	All	−0.901	<.001	6	view →
UCEC	All	All	−0.891	<.001	6	view →
LUAD	All	All	−0.327	.003	4	view →
READ	All	All	−0.796	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CPEB4–THCA

Open the THCA breakdown →