CPEB4

Across TCGA cell cohorts, CPEB4 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CPEB4-associated genes across cancer lineages are ELSPBP1, AMELY, and CLPS. Each is linked with CPEB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPEB4-to-partner and partner-to-CPEB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELSPBP1 grouped by CPEB4-low versus CPEB4-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPEB4→partner) and Y-score (partner→CPEB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ELSPBP1 →	+0.030	+4.807	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	AMELY →	+0.261	+4.736	<.001	.009	3	1
LUNG_NSCLC_LUAD	CLPS →	+0.132	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	TPD52L3 →	+0.395	+5.266	<.001	.001	3	1
BLOOD_Lymphoma	BMP15 →	+0.029	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	NLRP8 →	+0.041	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ELSPBP1 by CPEB4 expression — BLOOD_Myeloma

Explore this box plot interactively →