COX5B

Across TCGA patient cohorts, COX5B mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COX5B-associated genes across cancer lineages are MIR6775, HSPE1-MOB4, and IGHV3OR16-8. Each is linked with COX5B in more than 1 cancer types. Because this analysis shows association rather than direction, both COX5B-to-partner and partner-to-COX5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6775 grouped by COX5B-low versus COX5B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX5B→partner) and Y-score (partner→COX5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6775 →	+0.517	+2.756	.003	.006	3	1
UCEC	HSPE1-MOB4 →	+0.193	+3.654	.005	.003	3	1
UCEC	IGHV3OR16-8 →	+0.875	+3.535	.004	.007	3	1
UCEC	MIR6793 →	+0.753	+3.191	.004	.002	3	1
UCEC	IGHV4-4 →	+1.523	+4.175	<.001	<.001	3	1
UCEC	MIR4497 →	+0.478	+3.358	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

MIR6775 by COX5B expression — UCEC

Explore this box plot interactively →