COX5B

Across TCGA pan-cancer cohorts, COX5B RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated COX5B data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher COX5B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated COX5B expression acts as an unfavorable survival marker, although some lineages such as BLCA and SARC show a favorable association.

UVM, LUAD, and KICH are the cancer types where COX5B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	All	0.447	0.956	<.001	92	view →
LUAD	OS	Tertile	III,IV	0.448	0.789	.001	74	view →
KICH	DFS	Median	II,III,IV	0.550	1.000	.002	63	view →
LAML	DFS	Median	All	0.442	0.701	<.001	54	view →
UCS	DFS	Median	IV	0.367	0.952	.001	52	view →
ESCA	DFS	Tertile	III,IV	0.292	0.591	.002	48	view →
ACC	DFS	Median	All	0.254	0.677	<.001	39	view →
BLCA	DFS	Median	All	0.580	0.452	.010	37	view →
SARC	OS	Median	All	0.581	0.376	.003	19	view →
LIHC	OS	Median	III,IV	0.474	0.743	.010	18	view →
PRAD	DFS	Median	All	0.713	0.861	.011	18	view →
LGG	DFS	Quartile	All	0.680	0.818	.009	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

COX5B–UVM (OS)

Open the UVM breakdown →