COX5B

Across TCGA pan-cancer cohorts, COX5B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of COX5B’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where COX5B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COX5B is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

LIHC, LUSC, and LUAD are the cancer types where COX5B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COX5B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	All	+0.929	<.001	7	view →
LUSC	Male	II,III,IV	+0.811	<.001	7	view →
LUAD	All	All	+0.387	<.001	7	view →
UCEC	All	All	+0.814	<.001	6	view →
BRCA	All	III,IV	+0.401	.003	6	view →
HNSC	Female	IV	−0.566	.034	2	view →
KICH	All	All	−0.364	.019	2	view →
CHOL	All	All	+0.335	.015	2	view →
KIRC	Male	All	−0.316	.008	2	view →
BLCA	Male	IV	+0.380	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

COX5B–LIHC

Open the LIHC breakdown →