CORT

Across TCGA patient cohorts, CORT protein abundance is significantly associated with the RNA expression of many other genes, with 127 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CORT-associated genes across cancer lineages are VGLL1, CDK2AP1, and ESRRB. Each is linked with CORT in more than 1 cancer types. Because this analysis shows association rather than direction, both CORT-to-partner and partner-to-CORT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CORT versus VGLL1 in GBM, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CORT→partner) and Y-score (partner→CORT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VGLL1 →	+0.167	+0.356	.005	.006	3	1
GBM	CDK2AP1 →	-0.571	-0.529	<.001	<.001	3	1
GBM	ESRRB →	+0.605	+0.412	<.001	<.001	3	1
GBM	TNN →	-1.516	-0.493	.005	.002	3	1
GBM	WNK4 →	+1.220	+0.456	.004	.001	3	1
GBM	KLK8 →	+0.080	+0.419	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 127 associations by consensus.

CORT vs VGLL1 — GBM

Explore this scatter interactively →