CORT

Across TCGA pan-cancer cohorts, CORT RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CORT’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where CORT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CORT is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

BLCA, KICH, and LUSC are the cancer types where CORT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CORT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.474	<.001	8	view →
KICH	Female	All	−0.555	<.001	7	view →
LUSC	All	All	+0.334	<.001	5	view →
HNSC	All	IV	+0.180	.004	5	view →
LIHC	All	All	+0.108	.004	5	view →
BRCA	Female	II,III,IV	−0.213	<.001	4	view →
THCA	All	All	−0.163	.002	4	view →
LUAD	All	All	+0.186	.001	3	view →
CHOL	Male	All	+0.633	<.001	2	view →
UCEC	All	All	+0.300	.039	2	view →
COAD	Male	II,III,IV	−0.151	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CORT–BLCA

Open the BLCA breakdown →