COPZ1

Across TCGA patient cohorts, COPZ1 mutation is significantly associated with the RNA expression of many other genes, with 321 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPZ1-associated genes across cancer lineages are MIR4497, RNU6-905P, and RNU6-1178P. Each is linked with COPZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPZ1-to-partner and partner-to-COPZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4497 grouped by COPZ1-low versus COPZ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPZ1→partner) and Y-score (partner→COPZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4497 →	+0.410	+3.189	<.001	.001	3	2
SKCM	RNU6-905P →	+0.381	+4.513	<.001	.009	3	2
SKCM	RNU6-1178P →	+0.372	+4.594	.001	.008	3	1
SKCM	HSBP1P1 →	+0.450	+4.500	<.001	.005	3	1
SKCM	EXOGP1 →	+0.041	+5.797	<.001	.001	3	1
SKCM	RN7SL555P →	+0.137	+4.661	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 321 associations by consensus.

MIR4497 by COPZ1 expression — UCEC

Explore this box plot interactively →