COPB1

Across TCGA patient cohorts, COPB1 mutation is significantly associated with the RNA expression of many other genes, with 3,944 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPB1-associated genes across cancer lineages are BUB3, ATP5MC3, and CCT8. Each is linked with COPB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COPB1-to-partner and partner-to-COPB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by COPB1-low versus COPB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPB1→partner) and Y-score (partner→COPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.496	+1.625	<.001	.005	3	3
UCEC	ATP5MC3 →	+0.338	+1.638	.006	<.001	3	3
UCEC	CCT8 →	+0.327	+1.890	.003	.004	3	3
UCEC	GMEB1 →	+0.293	+2.056	.001	.001	3	3
UCEC	MRPS18C →	+0.286	+1.808	.002	.007	3	3
UCEC	SLBP →	+0.508	+2.424	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,944 associations by consensus.

BUB3 by COPB1 expression — UCEC

Explore this box plot interactively →