COPB1

Across TCGA pan-cancer cohorts, COPB1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of COPB1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where COPB1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COPB1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and BLCA are the cancer types where COPB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COPB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.690	<.001	10	view →
LIHC	Male	All	+0.832	<.001	9	view →
BLCA	All	III,IV	+0.499	<.001	9	view →
STAD	All	II,III,IV	+0.659	<.001	8	view →
BRCA	All	III,IV	+0.646	<.001	8	view →
THCA	Male	All	−0.369	.001	8	view →
COAD	Male	All	+0.427	<.001	6	view →
CHOL	All	All	+1.460	<.001	5	view →
LUAD	Male	All	+0.557	<.001	5	view →
KIRC	All	All	+0.216	.004	4	view →
KIRP	Female	II,III,IV	+0.796	.030	3	view →
LUSC	All	All	+0.326	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

COPB1–HNSC

Open the HNSC breakdown →