COMT

Across TCGA patient cohorts, COMT mutation is significantly associated with the RNA expression of many other genes, with 134 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible COMT-associated genes across cancer lineages are MIR4762, SLC25A5P4, and MIR8082. Each is linked with COMT in more than 1 cancer types. Because this analysis shows association rather than direction, both COMT-to-partner and partner-to-COMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4762 grouped by COMT-low versus COMT-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMT→partner) and Y-score (partner→COMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4762 →	+0.346	+4.867	<.001	.005	3	2
UCEC	SLC25A5P4 →	+0.154	+3.135	.002	.002	3	2
UCEC	MIR8082 →	+0.710	+3.239	<.001	.003	3	2
SKCM	RNU6-1248P →	+0.614	+4.215	.003	.009	3	2
SKCM	ATF4P1 →	+0.057	+4.765	<.001	.003	3	2
BLCA	AVP →	+0.705	+3.909	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 134 associations by consensus.

MIR4762 by COMT expression — SKCM

Explore this box plot interactively →