COMT

Across TCGA pan-cancer cohorts, COMT RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of COMT’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where COMT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COMT is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

COAD, HNSC, and KICH are the cancer types where COMT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COMT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.765	<.001	10	view →
HNSC	Male	III,IV	+0.775	<.001	10	view →
KICH	Female	II,III,IV	−1.771	<.001	8	view →
READ	All	II,III,IV	+1.110	<.001	7	view →
LUAD	Male	All	−0.686	<.001	7	view →
LIHC	All	All	−0.529	<.001	5	view →
STAD	All	All	+0.466	.002	4	view →
KIRC	Male	II,III,IV	−0.415	.014	3	view →
CHOL	Male	All	+0.955	.002	2	view →
THCA	Male	All	+0.279	.008	2	view →
BRCA	Female	II,III,IV	−0.247	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

COMT–COAD

Open the COAD breakdown →