COMMD7

Across TCGA patient cohorts, COMMD7 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COMMD7-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PDCD4, and Stathmin. Each is linked with COMMD7 in more than 1 cancer types. Because this analysis shows association rather than direction, both COMMD7-to-partner and partner-to-COMMD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by COMMD7-low versus COMMD7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD7→partner) and Y-score (partner→COMMD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.554	-2.986	.033	.037	3	1
UCEC	PDCD4 →	-0.829	-2.999	.002	.035	3	1
UCEC	Stathmin →	+0.197	+3.000	.013	.037	3	1
UCEC	INPP4B →	-0.399	-2.986	.033	.037	2	1
UCEC	Tuberin →	+0.330	+3.000	.034	.037	2	1
UCEC	Cyclin-E1 →	+0.534	+3.000	.034	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

p38-MAPK_pT180_Y182 by COMMD7 expression — UCEC

Explore this box plot interactively →