COMMD7

Across TCGA pan-cancer cohorts, COMMD7 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of COMMD7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where COMMD7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COMMD7 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, LIHC, and KICH are the cancer types where COMMD7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COMMD7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+0.523	<.001	12	view →
LIHC	Female	II,III,IV	+1.009	<.001	9	view →
KICH	Female	II,III,IV	−0.945	<.001	8	view →
COAD	Male	II,III,IV	+0.685	<.001	8	view →
STAD	Male	II,III,IV	+0.884	<.001	7	view →
BRCA	All	III,IV	+0.642	<.001	6	view →
THCA	All	IV	−0.537	<.001	6	view →
KIRP	All	All	+0.276	.011	6	view →
CHOL	All	All	+1.945	<.001	5	view →
ESCA	Male	All	+1.131	.005	4	view →
READ	All	II,III,IV	+0.547	.013	4	view →
HNSC	Female	All	+0.437	.014	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

COMMD7–KIRC

Open the KIRC breakdown →