COMMD7

Across TCGA pan-cancer cohorts, COMMD7 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated COMMD7 data layer compared with 6 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher COMMD7 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated COMMD7 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUAD show a favorable association.

UVM, LIHC, and LGG are the cancer types where COMMD7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.399	0.925	<.001	116	view →
LIHC	OS	Quartile	All	0.636	0.833	<.001	64	view →
LGG	OS	Median	All	0.745	0.871	<.001	51	view →
KICH	DFS	Tertile	III,IV	0.059	1.000	.004	45	view →
LAML	DFS	Median	All	0.443	0.689	<.001	38	view →
ACC	OS	Quartile	All	0.263	0.757	.001	29	view →
PAAD	DFS	Tertile	All	0.163	0.363	.008	21	view →
HNSC	OS	Tertile	All	0.445	0.745	.003	21	view →
KIRC	DFS	Quartile	III,IV	0.573	0.338	.015	20	view →
ESCA	OS	Tertile	All	0.588	0.772	.012	19	view →
LUAD	DFS	Tertile	IV	0.753	0.283	.036	18	view →
SKCM	DFS	Median	IV	0.569	0.167	.005	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

COMMD7–UVM (OS)

Open the UVM breakdown →