COMMD7

Across TCGA cell cohorts, COMMD7 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible COMMD7-associated genes across cancer lineages are ETDC, REG1B, and PRR20B. Each is linked with COMMD7 in more than 1 cancer types. Because this analysis shows association rather than direction, both COMMD7-to-partner and partner-to-COMMD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ETDC grouped by COMMD7-low versus COMMD7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD7→partner) and Y-score (partner→COMMD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ETDC →	+0.595	+4.415	<.001	.007	3	1
BREAST	REG1B →	+1.039	+5.169	<.001	.005	3	1
BREAST	PRR20B →	+0.049	+5.169	<.001	.005	3	1
BREAST	PRR20A →	+0.049	+5.169	<.001	.005	3	1
BREAST	PRR20D →	+0.049	+5.169	<.001	.005	3	1
BREAST	PRR20E →	+0.049	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ETDC by COMMD7 expression — LARGE_INTESTINE

Explore this box plot interactively →