Across TCGA patient cohorts, COMMD6 mutation is significantly associated with the RNA expression of many other genes, with 89 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible COMMD6-associated genes across cancer lineages are RPL36AP14, RNA5SP262, and CTSLP4. Each is linked with COMMD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both COMMD6-to-partner and partner-to-COMMD6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD6→partner) and Y-score (partner→COMMD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL36AP14 →	+0.171	+5.157	<.001	.007	3	2
BLCA	RNA5SP262 →	+2.459	+7.640	<.001	.009	3	2
SKCM	CTSLP4 →	+0.097	+4.730	<.001	.003	3	2
SKCM	RAB28P4 →	+0.111	+6.485	<.001	<.001	3	1
SKCM	MIR8067 →	+0.478	+5.993	<.001	.001	3	1
SKCM	TEX28 →	+0.036	+5.469	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

Exploration

COMMD6 survival (RNA) · tumor vs normal (RNA) · all COMMD6 data types