COMMD3-BMI1

Across TCGA patient cohorts, COMMD3-BMI1 mutation is significantly associated with the RNA expression of many other genes, with 274 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COMMD3-BMI1-associated genes across cancer lineages are MIR521-2, RN7SKP286, and RNA5SP410. Each is linked with COMMD3-BMI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COMMD3-BMI1-to-partner and partner-to-COMMD3-BMI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR521-2 grouped by COMMD3-BMI1-low versus COMMD3-BMI1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD3-BMI1→partner) and Y-score (partner→COMMD3-BMI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR521-2 →	+0.271	+8.055	<.001	.007	3	2
UCEC	RN7SKP286 →	+0.061	+4.475	<.001	.003	3	2
UCEC	RNA5SP410 →	+0.661	+2.789	<.001	<.001	3	2
BRCA	MIR6072 →	+0.319	+9.057	<.001	.003	3	1
BRCA	H3P46 →	+0.088	+7.731	<.001	.009	3	1
SKCM	LINC01817 →	+0.094	+5.469	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 274 associations by consensus.

MIR521-2 by COMMD3-BMI1 expression — BRCA

Explore this box plot interactively →