COMMD3-BMI1

Across TCGA pan-cancer cohorts, COMMD3-BMI1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated COMMD3-BMI1 data layer compared with 1 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher COMMD3-BMI1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated COMMD3-BMI1 expression acts as an unfavorable survival marker, although some lineages such as THYM and HNSC show a favorable association.

SCLC, LUAD, and UVM are the cancer types where COMMD3-BMI1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	All	0.538	0.822	.001	62	view →
LUAD	OS	Quartile	All	0.160	0.428	.002	53	view →
UVM	DFS	Median	All	0.321	0.725	.001	45	view →
UCEC	OS	Tertile	IV	0.210	0.548	.020	36	view →
READ	DFS	Tertile	All	0.265	0.731	.007	35	view →
COAD	DFS	Tertile	All	0.533	0.734	.001	30	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.413	.001	24	view →
THCA	OS	Tertile	III,IV	0.736	1.000	.006	23	view →
HNSC	DFS	Quartile	II,III,IV	0.787	0.661	.013	21	view →
KIRC	OS	Median	All	0.699	0.569	.001	18	view →
ACC	DFS	Median	All	0.574	0.724	.029	11	view →
STAD	DFS	Quartile	II,III,IV	0.693	0.452	.012	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

COMMD3-BMI1–SCLC (OS)

Open the SCLC breakdown →