COMMD10

Across TCGA patient cohorts, COMMD10 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COMMD10-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and eIF4E. Each is linked with COMMD10 in more than 1 cancer types. Because this analysis shows association rather than direction, both COMMD10-to-partner and partner-to-COMMD10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by COMMD10-low versus COMMD10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD10→partner) and Y-score (partner→COMMD10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.495	+2.827	<.001	.035	3	1
UCEC	PCNA →	+0.372	+3.000	.002	.036	2	1
UCEC	eIF4E →	+0.259	+3.000	.033	.037	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Caspase-7-cleavedD198 by COMMD10 expression — UCEC

Explore this box plot interactively →