COMMD10

Across TCGA pan-cancer cohorts, COMMD10 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated COMMD10 data layer compared with 2 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher COMMD10 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated COMMD10 expression acts as an unfavorable survival marker, although some lineages such as KIRC and ACC show a favorable association.

STAD, KIRC, and HNSC are the cancer types where COMMD10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Tertile	II,III,IV	0.288	0.552	<.001	106	view →
KIRC	OS	Median	All	0.733	0.529	<.001	83	view →
HNSC	OS	Quartile	II,III,IV	0.681	0.838	.001	83	view →
ESCA	DFS	Quartile	All	0.347	0.660	<.001	69	view →
UVM	DFS	Tertile	III,IV	0.226	0.854	.002	65	view →
SCLC	OS	Quartile	All	0.413	0.778	.004	41	view →
KICH	OS	Quartile	All	0.675	1.000	.011	37	view →
CESC	DFS	Tertile	All	0.740	0.874	.003	34	view →
LGG	OS	Tertile	All	0.715	0.886	<.001	32	view →
UCS	DFS	Tertile	III,IV	0.148	0.485	<.001	30	view →
LUAD	DFS	Tertile	III,IV	0.246	0.674	<.001	27	view →
LIHC	OS	Quartile	All	0.684	0.850	.002	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

COMMD10–STAD (OS)

Open the STAD breakdown →