COMMD10

Across TCGA pan-cancer cohorts, COMMD10 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of COMMD10’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where COMMD10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COMMD10 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

LIHC, LUSC, and THCA are the cancer types where COMMD10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COMMD10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	All	+0.861	<.001	9	view →
LUSC	All	II,III,IV	−0.549	<.001	8	view →
THCA	All	All	−0.232	.002	7	view →
BRCA	All	III,IV	+0.608	<.001	6	view →
CHOL	All	All	+1.213	<.001	5	view →
KICH	All	All	−0.566	.007	3	view →
LUAD	All	All	+0.259	.002	3	view →
COAD	All	II,III,IV	+0.409	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

COMMD10–LIHC

Open the LIHC breakdown →