COMMD10

Across TCGA cell cohorts, COMMD10 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,385 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible COMMD10-associated GO terms across cancer lineages are Dihydrofolate metabolic process, Positive regulation of ligase activity, and Positive regulation of centrosome duplication. Each is linked with COMMD10 in more than 10 cancer types. Because this analysis shows association rather than direction, both COMMD10-to-partner and partner-to-COMMD10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dihydrofolate metabolic process grouped by COMMD10-low versus COMMD10-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD10→partner) and Y-score (partner→COMMD10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Dihydrofolate metabolic process →	+0.166	+0.745	.006	.008	2	11
SOFT_TISSUE	Positive regulation of ligase activity →	+0.142	+0.834	<.001	<.001	3	10
BLOOD_Leukemia	Positive regulation of centrosome duplication →	+0.067	+0.633	<.001	<.001	3	9
SKIN	Protein neddylation →	+0.086	+0.534	.002	.003	3	9
BLOOD_Lymphoma	Regulation of centriole elongation →	+0.067	+0.895	<.001	<.001	3	8
OESOPHAGUS	Regulation of chromosome separation →	+0.154	+1.031	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,385 associations by consensus.

Dihydrofolate metabolic process by COMMD10 expression — LUNG_SCLC

Explore this box plot interactively →