COMETT

Across TCGA patient cohorts, COMETT RNA expression is significantly associated with the go_rna of many other GO terms, with 7,088 significant associations in total. STAD shows the largest number of these associations.

The most reproducible COMETT-associated GO terms across cancer lineages are Caveola assembly, Plasma membrane raft assembly, and Positive regulation of dopamine receptor signaling pathway. Each is linked with COMETT in more than 15 cancer types. Because this analysis shows association rather than direction, both COMETT-to-partner and partner-to-COMETT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveola assembly grouped by COMETT-low versus COMETT-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COMETT→partner) and Y-score (partner→COMETT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Caveola assembly →	+0.093	+0.110	<.001	<.001	3	16
TGCT	Plasma membrane raft assembly →	+0.087	+0.111	<.001	<.001	3	13
KICH	Positive regulation of dopamine receptor signaling pathway →	+0.083	+1.337	.001	.004	1	14
ESCA	Pyrimidine ribonucleoside monophosphate metabolic process →	+0.054	+0.144	<.001	.003	3	10
STAD	Ribonucleoside monophosphate metabolic process →	+0.039	+0.118	<.001	<.001	3	10
TGCT	Cell communication by electrical coupling →	+0.044	+0.154	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,088 associations by consensus.

Caveola assembly by COMETT expression — TGCT

Explore this box plot interactively →