cytosolic oncogenic antisense to MET transcriptGenealiases: COMET · LINC01510
Q-omics provides the consensus-scored COMETT profile across patient tissues and cancer cell-line models. COMETT expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, COMETT is differentially expressed in 9, with the highest sampling consensus in KIRP. Additionally, COMETT RNA expression shows 9,976 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KIRP, and TGCT as cancer lineages where COMETT shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for COMETT — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes COMETT survival associations across molecular data types. COMETT RNA expression shows survival associations in the most cancer types (20). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible COMETT RNA expression–survival associations across cancer types. High COMETT expression shows unfavorable associations in PAAD, STAD, BRCA and LGG, but favorable associations in KIRP and KIRC. The KIRP Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for COMETT RNA expression.
This table summarizes COMETT tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in KIRP for RNA.
This table ranks reproducible tumor–normal expression differences for COMETT. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. COMETT shows lower tumor expression in KIRP, KIRC and KICH and higher tumor expression in THCA, LUAD and HNSC. The KIRP box plot shows higher COMETT RNA expression in normal versus tumor tissue (log2 FC = −2.717, t-test p < 0.001).
This table shows molecular features associated with COMETT in patient tissues and cancer cell lines. In patient samples, COMETT shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
