COMETT

Across TCGA pan-cancer cohorts, COMETT RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated COMETT data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher COMETT RNA is associated with better overall survival. In most high-consensus cancer types, elevated COMETT expression acts as an unfavorable survival marker, although some lineages such as KIRP and KIRC show a favorable association.

KIRP, PAAD, and KIRC are the cancer types where COMETT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	All	0.988	0.834	<.001	105	view →
PAAD	OS	Median	All	0.272	0.493	<.001	81	view →
KIRC	OS	Median	All	0.706	0.549	<.001	78	view →
STAD	DFS	Quartile	IV	0.146	0.528	.005	65	view →
BRCA	DFS	Tertile	All	0.140	1.000	.001	54	view →
LGG	DFS	Tertile	All	0.594	0.772	<.001	45	view →
TGCT	DFS	Tertile	II,III,IV	0.554	0.996	.001	42	view →
THYM	DFS	Tertile	All	0.334	0.812	<.001	42	view →
DLBC	OS	Quartile	All	0.747	0.961	.013	39	view →
LIHC	OS	Median	II,III,IV	0.255	0.652	.001	16	view →
BLCA	OS	Tertile	All	0.654	0.751	.014	14	view →
COAD	OS	Quartile	IV	0.265	0.599	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

COMETT–KIRP (OS)

Open the KIRP breakdown →