COL6A5

Across TCGA cell cohorts, COL6A5 mutation is significantly associated with the RNA expression of many other genes, with 1,053 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COL6A5-associated genes across cancer lineages are IL3, SIAH3, and CHN2. Each is linked with COL6A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both COL6A5-to-partner and partner-to-COL6A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL3 grouped by COL6A5-low versus COL6A5-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL6A5→partner) and Y-score (partner→COL6A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IL3 →	+0.035	+3.954	<.001	<.001	3	2
SOFT_TISSUE	SIAH3 →	+0.575	+3.551	<.001	.004	3	2
SKIN	CHN2 →	-1.287	-3.459	.001	.001	3	2
LARGE_INTESTINE	EXOSC3 →	+0.424	+1.949	.001	.002	3	2
LARGE_INTESTINE	NEIL3 →	+0.565	+2.458	.004	<.001	3	2
LARGE_INTESTINE	SMU1 →	+0.437	+2.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,053 associations by consensus.

IL3 by COL6A5 expression — SOFT_TISSUE

Explore this box plot interactively →