COL6A5

Across TCGA pan-cancer cohorts, COL6A5 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of COL6A5’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where COL6A5 RNA is repressed in tumor relative to normal tissue. In most cancer types COL6A5 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and COAD are the cancer types where COL6A5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COL6A5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−1.318	<.001	11	view →
LUSC	Female	II,III,IV	−2.295	<.001	8	view →
COAD	Female	All	−0.373	<.001	7	view →
BLCA	All	III,IV	−0.541	.012	6	view →
BRCA	Female	II,III,IV	+0.103	<.001	4	view →
KIRC	Male	All	−0.072	.020	3	view →
THCA	All	All	+0.060	.001	3	view →
STAD	All	All	−0.219	.023	2	view →
KICH	Male	All	−0.052	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

COL6A5–LUAD

Open the LUAD breakdown →