COL6A1

Across TCGA patient cohorts, COL6A1 mutation is significantly associated with the RNA expression of many other genes, with 4,788 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL6A1-associated genes across cancer lineages are PINX1, RNU6-1228P, and CEP76. Each is linked with COL6A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL6A1-to-partner and partner-to-COL6A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PINX1 grouped by COL6A1-low versus COL6A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL6A1→partner) and Y-score (partner→COL6A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PINX1 →	+0.488	+1.818	<.001	<.001	3	4
CESC	RNU6-1228P →	+0.146	+4.144	<.001	.009	3	3
COAD	CEP76 →	+0.452	+2.348	<.001	.003	3	3
UCEC	C1QBP →	+0.487	+1.628	<.001	<.001	3	3
UCEC	NSD2 →	+0.401	+1.470	.001	<.001	3	3
UCEC	CHORDC1 →	+0.450	+2.209	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,788 associations by consensus.

PINX1 by COL6A1 expression — UCEC

Explore this box plot interactively →