COL6A1

Across TCGA pan-cancer cohorts, COL6A1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of COL6A1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where COL6A1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COL6A1 is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where COL6A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COL6A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+3.953	<.001	12	view →
KIRC	Male	III,IV	+1.006	<.001	11	view →
BLCA	Male	All	−1.471	.004	8	view →
UCEC	All	All	−1.849	<.001	6	view →
KICH	All	II,III,IV	+1.358	<.001	6	view →
BRCA	Female	All	+0.435	.001	6	view →
LUAD	All	III,IV	+0.944	.005	4	view →
THCA	All	All	−0.586	<.001	4	view →
CHOL	All	All	+1.056	.024	2	view →
PRAD	All	All	−0.771	<.001	2	view →
STAD	Male	II,III,IV	+1.218	.044	1	view →
LUSC	All	II,III,IV	+0.733	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

COL6A1–HNSC

Open the HNSC breakdown →