COL2A1

Across TCGA patient cohorts, COL2A1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL2A1-associated genes across cancer lineages are Caspase-7-cleavedD198, TFRC, and eIF4E. Each is linked with COL2A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL2A1-to-partner and partner-to-COL2A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by COL2A1-low versus COL2A1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL2A1→partner) and Y-score (partner→COL2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.936	+2.178	.011	.035	3	4
UCEC	TFRC →	+0.526	+1.906	.001	.014	3	4
UCEC	eIF4E →	+0.218	+3.820	.001	<.001	3	3
UCEC	BRCA2 →	-0.099	-1.574	.014	.034	3	3
UCEC	Cyclin-B1 →	+0.612	+3.000	<.001	<.001	3	3
LUAD	PKC-delta_pS664 →	-0.109	-3.157	.029	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Caspase-7-cleavedD198 by COL2A1 expression — COAD

Explore this box plot interactively →